Akademik Veri Yönetim Sistemi
LATIN AMERICAN JOURNAL OF PHARMACY, cilt.33, sa.4, ss.595-600, 2014 (SCI-Expanded)
In this study, simple and fast square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods were developed and validated for the determination of carvedilol in pharmaceutical preparations. The proposed methods were based on electrochemical oxidation of carvedilol at platinum electrode in acetonitrile solution containing 0.1 M LiClO4. The well-defined oxidation peak was observed at 1.24 V. The calibration curves were linear for carvedilol at the concentration range of 5-35 mu g/mL for SWV and DPV methods. Intra-and inter-day precision values for carvedilol were less than 3.57, and accuracy (relative error) was better than 2.38%. The mean recovery of carvedilol was 100.4% for pharmaceutical preparations. Developed methods in this study are accurate, precise and can be easily applied to Dilatrend, Carvexal and Coronis tablets as pharmaceutical preparation.