Simultaneous determination of rosuvastatin and amlodipine in binary mixtures by differential pulse voltammetry and HPLC methods
EURASIAN CHEMICAL COMMUNICATIONS, cilt.2, sa.8, ss.881-894, 2020 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2 Sayı: 8
- Basım Tarihi: 2020
- Doi Numarası: 10.33945/sami/ecc/ecc.2020.228276.1045
- Dergi Adı: EURASIAN CHEMICAL COMMUNICATIONS
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.881-894
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
This research study discusses two rapid, sensitive and specific methods for simultaneous determination of rosuvastatin (ROS) and amlodipine (AML) in pharmaceutical preparations using the differential pulse voltammetry (DPV) and high-performance liquid chromatography (HPLC). Electrochemical behavior and simultaneous voltammetric determination of ROS and AML were investigated using the platinum disk electrode. HPLC was also developed for the comparison. The flow rate of the mobile phase was 1.0 mL/min and all the detections were carried out at 225 nm using the UV detection. The calibration curve was established over the concentration range of 0.5-4 mu g/mL for DPV and 0.12 mu g/mL for HPLC. The intra- and inter-day relative standard deviation was less than 2.96 and 3.07% for DPV and HPLC, respectively. Limits of quantification were determined as 0.21 and 0.06 mu g/mL for DPV and HPLC, respectively. Both the drugs along with their degradation products were separated in less than 8 min. No interference was found from tablet excipients at the selected assay conditions. The methods were applied for the quality control of the commercial ROS and AML drug.