The protective effect of the cardiac thioredoxin system on the heart in the case of iron overload in mice.

Altun S., Budak H.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), cilt.64, ss.126704, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jtemb.2020.126704
  • Dergi Adı: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.126704
  • Anahtar Kelimeler: Iron overload, Oxidative stress, Thioredoxin system, Mouse heart, OXIDATIVE STRESS, INTERACTING PROTEIN, GLUTATHIONE DISULFIDE, REDOX REGULATION, GENE-EXPRESSION, DEFICIENCY, METABOLISM, REDUCTASE, INHIBITION, MECHANISMS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: Iron, which is essential for many vital biological processes, causes significant clinical pathologies in the case of its deficiency or excess. Cardiovascular protective pathways are activated by iron therapy. However, determining the appropriate iron concentration is essential to protect heart tissue from iron-induced oxidative stress. The thioredoxin system is one of the antioxidant systems that protect cells against oxidative stress. Moreover, it allows the binding of many transcription factors for apoptosis, myocardial protection, the stimulation of cell proliferation, and angiogenesis processes, especially the regulation of the cardiovascular system. This study's goal was to understand how iron overload affects the gene and protein levels of the thioredoxin system in the mouse heart.