The effects of Coenzyme Q10, Fullerene C60, α-Lipoic Acid on reproductive system of pubertal male rats exposed to Bisphenol A
REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS, cilt.35, sa.3, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.52973/rcfcv-e35716
- Dergi Adı: REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
- Anahtar Kelimeler: Bisphenol A, Coenzyme Q10, Fullerene C60, sperm, α-Lipoic Acid
- Atatürk Üniversitesi Adresli: Hayır
Özet
Bisphenol A is widely recognized as a significant toxic environmental contaminant globally, primarily due to its extensive industrial and commercial applications. The current study aimed to evaluate the potential of Coenzyme Q10, Carbon-60 fullerene and alpha-Lipoic Acid, which are known for their significant antioxidant capacity, to reduce the reproductive toxic effects induced by Bisphenol A in male rats. A total of sixty prepubertal male Sprague Dawley rats were assigned to eight experimental groups. The substances were applied by oral gavage at dose-adjusted levels, dissolved in olive oil and/or water, once per day for a duration of seven weeks. The rats were decapitated 24 hours subsequent to the final application thereafter blood and testicular tissues were taken for analysis. The exposure of Bisphenol A resulted in significant elevation in serum and testicular malondialdehyde level and significant reduction in the level of antioxidant enzymes. Epididymal sperm concentration and motility were considerably lower in the Bisphenol A-exposed group against the control group. Marked histopathological changes were evident in the testicular tissue, characterized by degeneration and a notable decrease in germinal cell. It was determined that administration of Coenzyme Q10 and alpha-Lipoic Acid significantly prevented Bisphenol A-induced oxidative stress and associated complications such as testicular dysfunction and the decreased epididymal sperm quality. In conclusion, Bisphenol A negatively affected the reproductive system biochemically, histologically and reproductively in male rats; Coenzyme Q10, Carbon-60 fullerene, and alpha-Lipoic Acid alleviated these negative effects.