Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.12, ss.1770-1778, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 12
- Basım Tarihi: 2018
- Doi Numarası: 10.2174/1871520618666180525085445
- Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1770-1778
- Anahtar Kelimeler: Azafluorenone, cytotoxicity, cell cycle, PARP, apoptosis, synthesis, OSCC cell line, II INHIBITORY-ACTIVITY, MONO MANNICH-BASES, TOPOISOMERASE-I, DNA-BINDING, ANTICANCER ACTIVITY, RATIONAL DESIGN, GLUTAMIC-ACID, DERIVATIVES, ALKALOIDS, THALIDOMIDE
- Atatürk Üniversitesi Adresli: Evet
Özet
Background: In this study, new azafluorenones, 4-(4-fluorophenyl)-2-(4-substitutedphenyl)-5H-indeno[1,2-b] pyridin-5-one, I1-I8 were synthesized and chemical structures were elucidated by spectral analysis. All compounds were reported for the first time here.