Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis

GÜL H. İ., TUĞRAK M., GÜL M., SAKAGAMİ H., UMEMURA N., ANIL B.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.12, ss.1770-1778, 2018 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 12
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1871520618666180525085445
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1770-1778
  • Anahtar Kelimeler: Azafluorenone, cytotoxicity, cell cycle, PARP, apoptosis, synthesis, OSCC cell line, II INHIBITORY-ACTIVITY, MONO MANNICH-BASES, TOPOISOMERASE-I, DNA-BINDING, ANTICANCER ACTIVITY, RATIONAL DESIGN, GLUTAMIC-ACID, DERIVATIVES, ALKALOIDS, THALIDOMIDE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: In this study, new azafluorenones, 4-(4-fluorophenyl)-2-(4-substitutedphenyl)-5H-indeno[1,2-b] pyridin-5-one, I1-I8 were synthesized and chemical structures were elucidated by spectral analysis. All compounds were reported for the first time here.