Neuroprotective Effects of Agmatine in Experimental Peripheral Nerve Injury in Rats: A Prospective Randomized and Placebo-Controlled Trial

SEZER A., GÜÇLÜ B., Kazanci B., ÇAKIR M., ÇOBAN M. K.

TURKISH NEUROSURGERY, cilt.24, sa.2, ss.196-201, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5137/1019-5149.jtn.7324-12.1
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.196-201
  • Anahtar Kelimeler: Agmatine, Axonotmesis, Neurotmesis, Peripheral nerve injury, Rat, SPINAL-CORD-INJURY, TRAUMATIC BRAIN-INJURY, LASER PHOTOTHERAPY, REGENERATION
  • Atatürk Üniversitesi Adresli: Evet

Özet

AIM: The purpose of this study was to demonstrate the activity of agmatine, an inducible nitric oxide synthase (iNOS) inhibitor and selective N-methyl-D-aspartate receptor (NMDAR) antagonist, on reducing tissue damage in distal part of traumatic nerve in an experimental rat peripheral nerve injury model.