Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation

Creative Commons License

Ün H., Uğan R. A., Gürbüz M. A., Bayır Y., Kahramanlar A., Kaya G., ...Daha Fazla

LIFE SCIENCES, cilt.266, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 266
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.lfs.2020.118869
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Phloretin, Phloridzin, Cisplatin, Nephrotoxicity, Mice, MAMMALIAN-CELLS, INJURY, HEAT-SHOCK-PROTEIN-70, ANTIOXIDANT, INCREASES, TOXICITY, EFFICACY, KIDNEY, TISSUE, ASSAY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aim: Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity.