Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation

Ün, Harun; Uğan, Rüstem; Gürbüz, Muhammet; Bayır, Yasin; Kahramanlar, Aysenur; Kaya, Gokce; Çadırcı, Elif; Halıcı, Zekai

doi:10.1016/j.lfs.2020.118869

Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation

Ün H., Uğan R. A., Gürbüz M. A., Bayır Y., Kahramanlar A., Kaya G., ...Daha Fazla

LIFE SCIENCES, cilt.266, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 266
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.lfs.2020.118869
Dergi Adı: LIFE SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: Phloretin, Phloridzin, Cisplatin, Nephrotoxicity, Mice, MAMMALIAN-CELLS, INJURY, HEAT-SHOCK-PROTEIN-70, ANTIOXIDANT, INCREASES, TOXICITY, EFFICACY, KIDNEY, TISSUE, ASSAY
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Atatürk Üniversitesi Adresli: Evet

Özet

Aim: Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity.