Evaluation of microcirculation in Buerger's disease using (201)thallium/(99m)technetium macroaggregated albumin scintigraphy

Ates A., Varoglu E., Yekeler I., Ozyazicioglu A.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.30, sa.4, ss.438-441, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 4
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1177/147323000203000412
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.438-441
  • Atatürk Üniversitesi Adresli: Evet

Özet

In the current study, 10 patients with Buerger's disease (thromboangiitis obliterans) and seven control patients with atherosclerosis obliterans (ASO) were evaluated for microvascular disturbance. After exercising for 1 min, patients were injected with 37 MBq (201)thallium (Tl-201) intra-arterially, and anterior planar images of the feet and whole body-images of the lower extremities were taken. The same procedure was repeated after 1 week using 185 MBq (99m)techetium macroaggregated albumin (Tc-99m-MAA). Rectangular regions of interest were drawn on the Tl-201 and Tc-99m-MAA images, and Tl-201/Tc-99m-MAA uptake ratios were calculated. Tl-201/Tc-99m-MAA ratios of the toes of those with Buerger's disease were significantly lower than those of ASO cases, whereas no significant difference was found for the lower limbs and feet. These findings may be explained by disturbances of microvascular regulation observed in Buerger's disease.