Adenosine receptors Adenozin reseptörleri
SENDROM, cilt.14, sa.5, ss.122-125, 2002 (Scopus)
- Yayın Türü: Makale / Kısa Makale
- Cilt numarası: 14 Sayı: 5
- Basım Tarihi: 2002
- Dergi Adı: SENDROM
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.122-125
- Atatürk Üniversitesi Adresli: Evet
Özet
The extracellular nucleoside adenosine has been intensively studied since 1929. Subsequent studies over the next four decades, receptors were classified in accordance with their preference for binding either adenosine (P1 receptor subtypes) or adenin nucleotides (P2 subtypes). P1 receptors were divided into A1 and A2 subtypes based on their ability to inhibit and stimulate cAMP accumulation respectively. The subsequent development of subtype-selective agonist and antagonist ligands facilitated the identification of A1 and A2 adenosine receptor proteins via photoaffinity labelling. Adenosine has a depressant action in the brain, heart, kidneys and other organs.