Akademik Veri Yönetim Sistemi
Cumhuriyet Science Journal, cilt.44, sa.3, ss.430-435, 2023 (Hakemli Dergi)
In the present study, the electroanalytical behaviour of clopidogrel was investigated by cyclic voltammetry method. The procedure was based on clopidogrel being electrochemically oxidized at a platinum electrode in nonaqueous solutions. At 1.93 V, the oxidation peak was noted. It was discovered that clopidogrel's oxidation was diffusion-controlled. Additionally, a quick and easy SWV approach was developed and validated in this work to determine clopidogrel in pharmaceutical preparations. At concentrations between 5 and 50 µg/mL, the calibration curve was linear. The precision was given by relative standard deviation and was less than 2.73%. Accuracy was given with relative error and did not exceed 3.89%. In pharmaceutical preparations, clopidogrel had an average recovery of 100.1%. Under the chosen experimental conditions, no interference was found. The suggested method is extremely accurate and precise. Therefore, the method is applicable to the measurement of clopidogrel in pharmaceutical formulations.