The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin

AKDEMİR F. N. E., Yildirim S., Kandemir F. M.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, cilt.29, sa.59, ss.89522-89529, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 59
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11356-022-22007-x
  • Dergi Adı: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, IBZ Online, ABI/INFORM, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Environment Index, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.89522-89529
  • Anahtar Kelimeler: Apoptosis, Cisplatin, Evodiamine, Liver toxicity, Oxidative stress, OXIDATIVE STRESS, PROCAINAMIDE HYDROCHLORIDE, LIVER-DAMAGE, RAT-LIVER, APOPTOSIS, CASPASES, TISSUE, MECHANISMS, THERAPY, KIDNEY
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups (n=6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS), and evodiamine+cisplatin (EVO+CIS) groups. All experimental processes were applied according to rules of ethical. Rats were sacrificed by high-dose anesthesia. Considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in the EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-alpha expressions were severe in the CIS group, whereas, in the EVO+CIS group, these expressions attenuated. According to all our findings, it can be expressed that evodiamine has beneficial effects against hepatotoxicity induced by experimental cisplatin administration