Akademik Veri Yönetim Sistemi
7 TH International Cukurova Agriculture and Veterinary Congress, Adana, Türkiye, 9 - 10 Mart 2024, ss.15-21
Gastric ulcer is a digestive system disease characterized by
damage to the structural integrity of the mucosa in the stomach tissue. Despite
the availability of current treatment protocols for this condition, its
tendency to recur frequently makes it one of the most serious health problems
in humans, negatively affecting their quality of life. This disease can
develop due to damage to the gastric mucosa and the influence of various
factors. Recent research has shown that Cyclooxygenase (COX) enzyme plays a
significant role in the development of gastric ulcers. The COX enzyme is a key
regulator of many biological processes in the body, including inflammation,
pain, and tissue repair, and plays a key role in the synthesis of
prostaglandins.
However, excessive or abnormal activity of the COX enzyme can weaken the
protective layer of the gastric mucosa, leading to the development of gastric
ulcers. Particularly, the release of COX-2 enzyme from inflammatory cells and
fibroblasts in the gastric mucosa has been identified as a significant factor
in the formation of gastric ulcers. Therefore, this review aims to examine the
role of COX enzyme and prostaglandins in the development of gastric ulcers.
Additionally, it will address the physiological functions of COX enzyme and
prostaglandins, their effects on the protective mechanisms of the gastric
mucosa, their roles in the treatment of gastric ulcers, and points to be
emphasized in future research.
Keywords: Cyclooxygenase (COX), Gastric
ulcer, Prostaglandin