Akademik Veri Yönetim Sistemi
journal of research in Clinical medicine, cilt.8, sa.1, ss.1-2, 2020 (Hakemli Dergi)
Introduction
On 31 December 2019, a cluster of pneumonia cases with
unknown etiology was reported in Wuhan city, Hubei
province of China. A novel coronavirus (SARS-CoV- 2)
was later detected as the causative agent and the clinical
condition was called coronavirus disease 19 (COVID-19).
The SARS-CoV-2 infection has a wide clinical course
that can progress from mild symptoms such as fever, sore
throat, cough to pneumonia and acute severe respiratory
failure. The S protein of SARS-CoV-2 is thought to bind
to the host cell angiotensin-converting enzyme 2 (ACE2)
receptor and cause the disease.
Case Presentation
An 82-year-old male patient presented to the emergency
room with fever and cough. He had a history of diabetes
mellitus, hypertension, Parkinson’s disease and coronary
bypass, been on a regular prescription of metformin,
rasagiline, telmisartan and hydrochlorothiazide. A
prescription was issued to treat bacterial pneumonia and
he was discharged with a plan of outpatient follow-up
by the department of pulmonology. Three days later, he
came back to the emergency department as his complaints
continued. As the patient had bilateral infiltrations on the
thorax CT-scan, consultation from specialists in infectious
diseases and pulmonology departments was requested.
Viral pneumonia was considered by the consultants
as the possible diagnosis; oseltamivir was added to his
treatment and an outpatient follow-up for five days was
recommended. Because of his increasing complaints and
additional shortness of breath despite the treatment, he
was referred to us at the emergency department following
a review appointment at the pulmonology outpatient
clinic.
In physical examination, the patient appeared alert,
oriented and cooperative with the following vital signs:
temperature 36.7ºC, pulse rate of 88 beats/minute,
respiratory rate of 18 per minute, blood pressure of
182/106 mm Hg, and oxygen saturation of 90%. His
breathing was spontaneous and unaided. Bilateral rales
and rhonchi were detected in lung auscultation. Other
system findings were normal.
In laboratory tests; lymphocyte count was 0.8 × 103
cells/µL, serum sodium: 115 mmol/L, C-reactive protein
(CRP): 30 mg/L, lactate: 2.1 mmol/L. There were bilateral
peripheral infiltrations in HRCT (Figure 1). The SARSCoV-2 serology test was positive, he was therefore
hospitalized in an isolated bed in intensive care unit.
Serum sodium values and lymphocyte counts of the recent
hospital admission are displayed in Figure 2.
Discussion
SARS-CoV-2 interacts strongly with ACE2 in human cells
due to S-protein.1,2 Therefore, cells expressing ACE2 are
at high risk for SARS-CoV-2 infection.3
SARS-CoV-2
binds to type 2 alveolar cells in the lung through the
ACE2 receptor, causing the disease. Therefore, in a study
comparing ACE2 expression rates in other organs, lung
ACE2 expression rate was accepted as the reference value.3
Other high-risk organ cells for SARS-CoV-2 infection
include ileum epithelial cells, myocardial cells and kidney
proximal tubule cells.3
Xu et al reported that ACE2
receptors were also interestingly expressed in lymphocytes
in oral mucosa; SARS-CoV-2 attacked lymphocytes
resulting in increased morbidity of the patients.4
It
was noted that the reported symptoms of COVID-19
(dyspnea, diarrhea, acute heart damage, kidney failure)
could be associated with fusion of the virus into the cells
in high risk organs, especially in the presence of viremia.3
ACE inhibitors, angiotensin type 1 receptor blockers and
angiotensin type 2 receptor agonist drugs increase ACE2
expression in renal proximal tubule cells and it is well
known that hyponatremia may occur due to these drugs.5
In a large-scale study with 1099 patients, 15% had
Case Report
*Corresponding Author: Muhammed Yaşar Sever, Email: ed.dr.muhammed@gmail.com
© 2020 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (http://
creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original
work is properly cited.
TUOMS
P R E S S
Received: 13 Apr. 2020, Accepted: 22 May 2020, e-Published: 7 June 2020
Sever et al
2 J Res Clin Med, 2020, 8: 22
hypertension and mean serum sodium value of 138
mmol/L. In addition, lymphopenia was reported in 82.3%
of patients at the time of admission.6
As noted above, our
patient had been on a regular prescription of a combination
of telmisartan and hydrochlorothiazide for some period
prior to his presentation to our department. It is important
to note that from the onset of his symptoms, this patient
continued to display increasing clinical symptoms and
worsening hyponatremia with lymphopenia (Figure 2).