Impact of Rho-Kinase Inhibitor Hydroxyfasudil in Protamine Sulphate Induced Cystitis Rat Bladder

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Akin Y., BOZKURT A., Erol H. S., Halici M. B., ÇELEBİ F., Kapakin K. A., ...More

LUTS-LOWER URINARY TRACT SYMPTOMS, vol.7, no.2, pp.108-114, 2015 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 7 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1111/luts.12058
  • Journal Name: LUTS-LOWER URINARY TRACT SYMPTOMS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.108-114
  • Keywords: antioxidants, bladder overactivity, interstitial cystitis, oxidative stress, rho-kinase inhibitors, URINARY GLYCOSAMINOGLYCANS, PAIN, SYMPTOMS, MUSCLE, INJURY, MODEL
  • Ataturk University Affiliated: Yes

Abstract

ObjectivesThe objective of the present study was to evaluate anti-inflammatory effects of hydroxyfasudil in a protamine sulfate (PS) induced cystitis rat model. Additionally, we investigated prevention of bladder overactivity (BO), and tissue damage in these experiments.