A novel approach for the synthesis of β-keto esters: One-pot reaction of carboxylic acids with chlorosulfonyl isocyanate

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Atmaca U.

Arkivoc, cilt.6, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.24820/ark.5550190.p011.209
  • Dergi Adı: Arkivoc
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Directory of Open Access Journals
  • Anahtar Kelimeler: beta-Keto ester, chlorosulfonyl isocyanate, carboxylic acid, trifluoroacetic acid, one-pot, ACYLATION
  • Atatürk Üniversitesi Adresli: Evet

Özet

© AUTHOR(S).β-Keto esters were synthesized by direct carboxylation of various 4- and 5-oxo-carboxylic acid derivatives in the presence of chlorosulfonyl isocyanate in excellent yield under mild conditions. Additionally, optimization conditions were examined for synthesis β-keto esters. Finally, it has been found that trifluoroacetic acid is efficient in DCM under optimized conditions. This efficient one-pot novel method is very usefull, fair price and easy to handle of β-keto esters.