Tailoring magnesium alloys via plasma electrolytic oxidation: Emerging drug delivery pathways in biodegradable implant technologies – A review
Journal of Drug Delivery Science and Technology, cilt.124, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 124
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.jddst.2026.108581
- Dergi Adı: Journal of Drug Delivery Science and Technology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Anahtar Kelimeler: Controlled release, Drug delivery, Mg-based alloy, Plasma electrolytic oxidation (PEO), Surface topography
- Atatürk Üniversitesi Adresli: Evet
Özet
Biodegradable metallic implants, especially magnesium (Mg)-based systems, represent a novel category of biomaterials intended to resolve the shortcomings of permanent devices. Their mechanical compatibility with bone and gradual resorption in vivo makes them attractive for clinical use. However, rapid and uncontrolled degradation remains a major challenge. To address this, multifunctional coatings have been engineered to enhance corrosion protection, biological compatibility, and enable localized drug delivery. Among surface modification techniques, plasma electrolytic oxidation (PEO) is distinguished by generating dense, adherent, and tunable oxide layers on Mg substrates. These coatings not only enhance stability but also serve as platforms for controlled drug release. By tailoring surface morphology and porosity, PEO-treated surfaces can be further functionalized to regulate therapeutic agent release. Recent studies show that post-treatment strategies allow precise control over coating architecture, directly influencing drug loading and release kinetics. This review highlights current advancements in drug delivery using PEO coatings on Mg, emphasizing how surface engineering enables predictable and sustained release profiles for bone regeneration and other biomedical applications.