Akademik Veri Yönetim Sistemi
NEUROSURGERY QUARTERLY, cilt.23, sa.4, ss.230-234, 2013 (SCI-Expanded)
Objective/Background:A growing list of studies gives evidence for the efficacy of progesterone in the nervous systems. Neuroprotective effects of progesterone are well documented for the injured brain models in the literature. However, the effects of progesterone on spinal cord injury (SCI) should be investigated.Methods:Twenty adult male Wistar-Albino rats were included in the study. The rats were randomly allocated into two groups (Control and Progesterone). Progesterone was administered in five days at a dose of 4 mg/kg via intraperitoneal route. Each group underwent motor examination in sixth weeks using Basso, Beattie and Bresnehan (BBB) locomotor test.Results:The score mean values of the control and study groups receiving progesterone treatment after six weeks were 11.40.427 and 14.1 +/- 0.526, respectively (P<0.05). While the improvement process showed a nearly parallel course between the two groups until the end of the third week, the progesterone treated group exhibited a significant difference in BBB scores relative to the control starting from the fourth week (P<0.05). On the examined histological sections, it was determined that progesterone had clear neuroprotective effects.Conclusions:The results supported the fact that progesterone could be a potentially effective therapeutic strategy to treat SCI.