Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives

OZTASKIN N., ÇETİNKAYA Y., TASLIMI P., GÖKSU S., GÜLÇİN İ.

BIOORGANIC CHEMISTRY, cilt.60, ss.49-57, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.bioorg.2015.04.006
  • Dergi Adı: BIOORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.49-57
  • Anahtar Kelimeler: Acetylcholinesterase, Antioxidant activity, Bromophenols, Diarylmethanones, Demethylation, Enzyme inhibition, RADICAL-SCAVENGING ACTIVITY, MARINE NATURAL-PRODUCTS, IN-VITRO ANTIOXIDANT, ANHYDRASE ISOENZYMES INHIBITORS, ALGA SYMPHYOCLADIA-LATIUSCULA, STRUCTURE-ACTIVITY INSIGHT, CHIONANTHUS-VIRGINICUS L., CARBONIC-ANHYDRASE, SULFONAMIDE DERIVATIVES, ANTIBACTERIAL ACTIVITY
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were obtained from the acylation reactions of benzoic acids with substituted benzenes. One of the bromodiarylmethanone was synthesized from the bromination of diarylmethanone with molecular bromine. All diarylmethanones were converted into their bromophenol derivatives with BBr3. The antioxidant activities of all synthesized compounds were elucidated by using various bioanalytical assays. Radical scavenging activities of compounds 10-24 were evaluated by means of DPPH center dot and ABTS(center dot+) scavenging activities. In addition, reducing ability of 10-24 were determined by Fe3+, Cu2+, and [Fe3+-(TPTZ)(2)](3) reducing activities. alpha-Tocopherol, trolox, BHA, and BHT were used as positive antioxidant and radical scavenger molecules. On the other hand, IC50 values were calculated for DPPH center dot, ABTS(center dot+) scavenging, and AChE inhibition effects of novel compounds. The results obtained from the current studies clearly show that novel bromophenol derivatives 20-24 have considerable antioxidant, antiradical, and AChE inhibition effects. (C) 2015 Elsevier Inc. All rights reserved.