Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers

HALICI Z., Polat B., ÇADIRCI E., TOPCU A., Karakus E., KÖSE D., ...Daha Fazla

CHEMICO-BIOLOGICAL INTERACTIONS, cilt.258, ss.266-275, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 258
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.cbi.2016.09.011
  • Dergi Adı: CHEMICO-BIOLOGICAL INTERACTIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.266-275
  • Anahtar Kelimeler: Aliskiren, Cytokine, Indomethacin, Renin angiotensin aldestron system, Ulcer, SMOOTH-MUSCLE-CELLS, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, OXIDATIVE STRESS, RECEPTOR ANTAGONIST, INDUCED LESIONS, MUCOSAL DAMAGE, NITRIC-OXIDE, INFLAMMATION, TELMISARTAN, PROTECTS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Purpose: Previously blocking the renin angiotensin system (RAAS) has been effective in the prevention of gastric damage. Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin blockage, in indomethacin-induced gastric damage model.