Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers


HALICI Z. , Polat B. , ÇADIRCI E. , TOPCU A., Karakus E. , KÖSE D. , et al.

CHEMICO-BIOLOGICAL INTERACTIONS, cilt.258, ss.266-275, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 258
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.cbi.2016.09.011
  • Dergi Adı: CHEMICO-BIOLOGICAL INTERACTIONS
  • Sayfa Sayısı: ss.266-275

Özet

Purpose: Previously blocking the renin angiotensin system (RAAS) has been effective in the prevention of gastric damage. Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin blockage, in indomethacin-induced gastric damage model.