Metallic Nanoparticle-Decorated Polydopamine Thin Films and Their Cell Proliferation Characteristics

AYSİN F., YILMAZ A., YILMAZ M.

COATINGS, cilt.10, sa.9, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 9
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3390/coatings10090802
  • Dergi Adı: COATINGS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Applied Science & Technology Source, Communication Abstracts, INSPEC, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
  • Anahtar Kelimeler: polydopamine thin films, cell proliferation, gold nanoparticles, silver nanoparticles, cell viability, MUSSEL-INSPIRED POLYDOPAMINE, SURFACE MODIFICATION, ADHESION, DOPAMINE, ANTIBACTERIAL, BIOMATERIALS, DEPOSITION, VERSATILE, SCAFFOLD
  • Atatürk Üniversitesi Adresli: Evet

Özet

Plasmonic metal nanoparticle (NP)-decorated thin films of biobased and biocompatible polymers provide significant opportunities in various biomedical applications. Inspired from the adhesive proteins of the marine mussels, polydopamine (PDA) serves as a versatile, biocompatible, and simple thin-film material and enhances cell growth and proliferation. Herein, we report the fabrication of the gold NPs (AuNPs) or silver NPs (AgNPs)-deposited thin films of PDA and their employment in cell growth and proliferation. PDA thin film with its numerous functional groups enabled well-controlled adsorption of NPs. The number density of NPs was manipulated simply by tuning the deposition time. Cell viability test for human lung cancer (A549) and human colon cancer (CaCO2) cell lines indicated that a thin layer of PDA film remarkably enhanced the cell growth and proliferation. The lower number density of NPs for the 24 h of the culture time resulted in a higher proliferation rate. However, the increase in both the number density of NPs and culture time led to a decrease in cell growth.