Expression of chemerin in the synovial fluid of patients with temporomandibular joint disorders

Kaya G. S., YAVUZ G. Y., Kiziltunc A.

JOURNAL OF ORAL REHABILITATION, cilt.45, sa.4, ss.289-294, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/joor.12608
  • Dergi Adı: JOURNAL OF ORAL REHABILITATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.289-294
  • Anahtar Kelimeler: chemerin, disorder, synovial fluid, temporomandibular joint, NECROSIS-FACTOR-ALPHA, INTERNAL DERANGEMENT, RECEPTOR CHEMR23, PROTEIN, ARTHROCENTESIS, OSTEOARTHRITIS, ANGIOGENESIS, FIBROBLASTS, LIGAND, CELLS
  • Atatürk Üniversitesi Adresli: Evet

Özet

The synovial membrane and fluid are significantly involved in the pathogenesis of temporomandibular joint (TMJ) disorders. This study aimed to investigate the relation between levels of chemerin in the synovial fluid (SF) of patients with TMJ disorder and their relationship. Sixty samples of SF were obtained from patients with an internal derangement (ID) or osteoarthritis (OA). Chemerin in the SF was examined by enzyme-linked immunosorbent assay (ELISA). The results showed greater levels of chemerin in the SF of patients with OA than ID. While chemerin levels were positively correlated with pain scores, they were inversely correlated with MMO. Chemerin levels increased progressively as the disorder stage became more severe. The findings of this study suggest that chemerin in SF may play role as a predisposing factor and may represent a novel potential prognostic biochemical marker in the pathogenesis of TMJ disorders.