Sedative effect of Centranthus longiflorus ssp longiflorus in rats and the influence of adrenalectomy on its effect

Suleyman H., Guvenalp Z., Kizilkaya M., Demirezer L. O.

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, cilt.127, sa.8, ss.1263-1265, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 127 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1248/yakushi.127.1263
  • Dergi Adı: YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1263-1265
  • Anahtar Kelimeler: Centranthus longiflorus ssp longiflorus, sedative effect, rat, thiopental sodium, EXTRACTS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Sedative effect of the aqueous extract of Centranthus longiflorus ssp. longiflorus (Cle-1) on intact and adrenalectomized rats was investigated using a thiopental sleeping test to clarify the relationship of this effect on adrenal gland hormones, particularly glucocorticoids. Adrenal gland hormones were found to play an important role in inhibiting the sedative effect of the investigated drugs. It is clear, however, that these hormones are not glucocorticoids. Glucocorticoids were not responsible for shortening the sleep period.