DETERMINATION OF PRILOCAINE HCl IN PHARMACEUTICAL PREPARATION AND HUMAN PLASMA WITH SPECTROPHOTOMETERY
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, cilt.3, sa.4, ss.1018-1021, 2012 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 3 Sayı: 4
- Basım Tarihi: 2012
- Doi Numarası: 10.13040/ijpsr.0975-8232.3(4).1018-21
- Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
- Derginin Tarandığı İndeksler: Other Indexes
- Sayfa Sayıları: ss.1018-1021
- Atatürk Üniversitesi Adresli: Evet
Özet
A simple and sensitive spectrophotometric method was developed for the determination of prilocaine HCl in pharmaceutical preparation and human plasma. The quantitative analysis of prilocaine HCl was carried out using of wavelength at 230 nm. The method was linear in concentration range of 3-15 mu g/mL for standard solution and 4-15 mu g/mL for human plasma. Linearity was determined by calculating correlation coefficient. These values were found as a 0.9999 and 0.9967 in standard solution and human plasma, respectively. Developed spectrophotometric method was found suitable in terms of accuracy, sensitivity, precision, reproducibility. In addition to these, this method could be easily and directly applied to both human plasma and pharmaceutical preparation.