Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19

Altay O., Arif M., Li X., Yang H., Aydin M., Alkurt G., ...Daha Fazla

ADVANCED SCIENCE, cilt.8, sa.17, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 17
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/advs.202101222
  • Dergi Adı: ADVANCED SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, Compendex, INSPEC, Directory of Open Access Journals
  • Anahtar Kelimeler: combined metabolic activators, COVID-19, metabolomics, omics data, proteomics, NICOTINAMIDE RIBOSIDE, ARGININE, KYNURENINE, NAD(+), SUPPLEMENTATION, COMBINATION, GLUTATHIONE, SERINE, MODEL
  • Atatürk Üniversitesi Adresli: Evet

Özet

COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD(+)) and glutathione metabolism. Here it is investigated if administration of a mixture of combined metabolic activators (CMAs) consisting of glutathione and NAD+ precursors can restore metabolic function and thus aid the recovery of COVID-19 patients. CMAs include l-serine, N-acetyl-l-cysteine, nicotinamide riboside, and l-carnitine tartrate, salt form of l-carnitine. Placebo-controlled, open-label phase 2 study and double-blinded phase 3 clinical trials are conducted to investigate the time of symptom-free recovery on ambulatory patients using CMAs. The results of both studies show that the time to complete recovery is significantly shorter in the CMA group (6.6 vs 9.3 d) in phase 2 and (5.7 vs 9.2 d) in phase 3 trials compared to placebo group. A comprehensive analysis of the plasma metabolome and proteome reveals major metabolic changes. Plasma levels of proteins and metabolites associated with inflammation and antioxidant metabolism are significantly improved in patients treated with CMAs as compared to placebo. The results show that treating patients infected with COVID-19 with CMAs lead to a more rapid symptom-free recovery, suggesting a role for such a therapeutic regime in the treatment of infections leading to respiratory problems.