Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats

Arpaci H., Comu F. M., Kucuk A., Kosem B., Kartal S., ŞIVGIN V., ...Daha Fazla

Drug Design Development and Therapy, cilt.10, ss.2477-2481, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2147/dddt.s113806
  • Dergi Adı: Drug Design Development and Therapy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2477-2481
  • Anahtar Kelimeler: rat, lornoxicam, iv ibuprofen, erythrocyte deformability, blood flow, ISCHEMIA-REPERFUSION INJURY, HYPERTENSION, CELL
  • Atatürk Üniversitesi Adresli: Hayır

Özet

Background: Change in blood supply is held responsible for anesthesia-related abnormal tissue and organ perfusion. Decreased erythrocyte deformability and increased aggregation may be detected after surgery performed under general anesthesia. It was shown that nonsteroidal anti-inflammatory drugs decrease erythrocyte deformability. Lornoxicam and/or intravenous (iv) ibuprofen are commonly preferred analgesic agents for postoperative pain management. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg, iv) and ibuprofen (30 mg/kg, iv) on erythrocyte deformability, as well as hepatic and renal blood flows, in male rats.