The serum amino acid profile in COVID-19

ATİLA A., ALAY H., YAMAN M. E., Akman T. C., ÇADIRCI E., BAYRAK B., ...Daha Fazla

AMINO ACIDS, cilt.53, sa.10, ss.1569-1588, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00726-021-03081-w
  • Dergi Adı: AMINO ACIDS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1569-1588
  • Anahtar Kelimeler: Amino acid, COVID-19, BCAAs, l-2-aminobutyric acid, L-phenylalanine, Taurine, GLUTAMINE-METABOLISM, ARGININE, PROLINE, LYMPHOCYTES, SPLENOCYTES, MACROPHAGES, CITRULLINE, HYBRIDOMA, GLUCOSE, EVENTS
  • Atatürk Üniversitesi Adresli: Evet

Özet

The pandemic of the coronavirus disease (COVID-19) caused by SARS-CoV-2 affects millions of people worldwide. There are still many unknown aspects to this infection which affects the whole world. In addition, the potential impacts caused by this infection are still unclear. Amino acid metabolism, in particular, contains significant clues in terms of the development and prevention of many diseases. Therefore, this study aimed to compare amino acid profile of COVID-19 and healthy subject. In this study, the amino acid profiles of patients with asymptomatic, mild, moderate, and severe/critical SARS-CoV-2 infection were scanned with LC-MS/MS. The amino acid profile encompassing 30 amino acids in 142 people including 30 control and 112 COVID-19 patients was examined. 20 amino acids showed significant differences when compared to the control group in COVID-19 patient groups with different levels of severity in the statistical analyses conducted. It was detected that the branched-chain amino acids (BCAAs) changed in correlation with one another, and l-2-aminobutyric acid and l-phenylalanine had biomarker potential for COVID-19. Moreover, it was concluded that l-2-aminobutyric acid could provide prognostic information about the course of the disease. We believe that a new viewpoint will develop regarding the diagnosis, treatment, and prognosis as a result of the evaluation of the serum amino acid profiles of COVID-19 patients. Determining l-phenylalanine and l-2-aminobutyric levels can be used in laboratories as a COVID-19-biomarker. Also, supplementing COVID patients with taurine and BCAAs can be beneficial for treatment protocols.