The role of melatonin in preventing radiation-induced intestinal injury

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Sezen O., Erdemci B., Çalık M., Koc M.

JOURNAL OF BUON, cilt.26, sa.2, ss.626-633, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 2
  • Basım Tarihi: 2021
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.626-633
  • Anahtar Kelimeler: intestinal injury, melatonin, radiation enteritis, radioprotective, radiotherapy, OXIDATIVE ORGAN DAMAGE, ENTERITIS, RADIOTHERAPY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Purpose: Despite the therapeutic effects of radiotherapy on tumor cells, it has potential severe adverse effects on the sur- rounding normal tissues. Acute or chronic intestinal adverse effects that are likely to occur in patients undergoing radio- therapy for pelvic and abdominal cancers lead to increased morbidity, significant impairment of the quality of life, and economic losses. Various biological, chemical and pharma- cological agents are being tested to protect from and to treat radiation enteritis. This experimental study aimed to inves- tigate the protective effects of melatonin against radiation induced intestinal injury when administered before radiation exposure in rats.