Naked-eye fluorescence sensing of aluminum using a bis(rhodamine)-phenyl hybrid for environmental monitoring and in vitro/in vivo bioimaging
Microchimica Acta, cilt.193, sa.7, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 193 Sayı: 7
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s00604-026-08250-w
- Dergi Adı: Microchimica Acta
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Engineering Source (EBSCO), Health Research Premium Collection (ProQuest), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Anahtar Kelimeler: Aluminum, Cyanide, Daphnia magna, Living cells imaging, RGB-analysis, Rhodamine
- Atatürk Üniversitesi Adresli: Evet
Özet
A new probe, Rh-Ph-Rh, featuring two rhodamine groups attached to a phenyl ring, was developed. This hybrid compound serves multiple purposes: it turns on with a strong fluorescent signal in the presence of aluminum ions (Al3+) and can detect them at concentrations as low as 358 nM. When both Al3+ and cyanide ions (CN⁻) are present, fluorescence is quenched, enabling sensitive detection of CN¯ (619 nM). Beyond sensing, Rh-Ph-Rh can act as a molecular “memory” unit and displays notable electrical properties. Practical applications include rapid detection of Al3+ and CN⁻ ions using filter paper strips and smartphone-based RGB colorimetric analysis. In biological assays using MCF-7 cancer cells, Rh-Ph-Rh exhibited anticancer effects that increased with higher doses (IC50 = 31.357 µg/mL), enabling fluorescence-based imaging of aluminum ions within cells. Tests in live Daphnia magna (water fleas) confirmed that a visible green glow could selectively identify Al3+. Taken together, these results suggest that Rh-Ph-Rh could be a valuable tool for environmental monitoring, biological imaging, and cancer treatment and diagnosis.