Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties

Cagatay E., AKYILDIZ V., Ergun Y., AYAR KAYALI H.

CHEMISTRY & BIODIVERSITY, cilt.18, sa.11, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 11
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/cbdv.202100348
  • Dergi Adı: CHEMISTRY & BIODIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: murrayaquinone A, organic synthesis, anti-tumor activity, colon cancer cell lines, CELL-CYCLE ARREST, HYDROGEN-PEROXIDE, OXIDATIVE STRESS, SERUM-ALBUMIN, APOPTOSIS, CANCER, BINDING, DEATH, CARBAZOLEQUINONES, CYTOTOXICITY
  • Atatürk Üniversitesi Adresli: Evet

Özet

A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.