Akademik Veri Yönetim Sistemi
7th INTERNATIONAL CUKUROVA AGRICULTURE AND VETERINARY CONGRESS, Adana, Türkiye, 9 - 10 Mart 2024, ss.976-983
Acrylamide (ACR) is a chemical that is widely used in many areas and can cause damage
to many tissues and organs. It occurs as a result of heat treatment of foods containing
mainly carbohydrates and proteins. In this study, the effects of gallic acid (GA) on kidney
damage induced by ACR in rats were investigated. A total of 40 male Sprague Dawley
rats were used in our study and the rats were divided into five experimental groups which
Control, ACR, ACR+GA50, ACR+GA100 and GA100. In the experiment, ACR was
applied to the ACR groups at a dose of 50 mg/kg, while Gallic acid (GA) was applied to
the GA groups at doses of 50 and 100mg/kg. At the end of the 14-day experiment, the
rats were euthanized and their kidney tissues were removed. In order to determine
whether oxidative stress developed in kidney tissues taken from rats, the nuclear factor
erythroid 2–related factor 2 (Nrf-2) and heme oxygenase-1 (HO-1) levels were
determined by using the ELISA method. While both Nrf-2 and HO-1 levels decreased
significantly in the groups treated with ACR, there was an increase in the kidney tissues
of the treated rats with GA. As a result, in this study was determined that GA had a
protective effect against ACR-induced renal oxidative stress and this protective effect was
achieved especially with high doses of GA.