Akademik Veri Yönetim Sistemi
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.99, sa.105978, ss.1-14, 2024 (SCI-Expanded)
Inhalation therapy is one of the methods for treating pulmonary diseases such as asthma, chronic obstructive pulmonary disease, and lung infections. Thus, prediction of local deposition of inhaled particles is crucial for the assessment of their therapeutic effects. However, there are limited studies that performed under realistic respiratory conditions, especially with respect to targeted drug delivery. The main goal of this study is to numerically investigate the regional transport and deposition of the aerosol particles in a realistic human airway model during the circulatory breathing conditions. In the simulations, three different circulatory breathing conditions and the aerosol particle sizes were conducted. Results obtained from simulations suggest that the distribution and deposition of the particles were significantly affected by the inhalation flow rate, the particle size, and the type of breathing conditions. The particle deposition efficiencies increased with flow rate and particle size. Most of particles deposited in the extrathoracic region before reaching the bronchial region. It is advisable to avoid selecting a high inhalation flow rate for the effective treatment of bronchial diseases. Both the particle distribution fraction and the deposition efficiency were higher in the right lung compared to the left lung. Thus, it can be said that the right lung will absorb more drugs and be more effective in treating the diseases. For the treatment of the left lung diseases, the inhalation flow rate should be increased appropriately. However, it should not be forgotten that this situation can increase a possible health risk by inhaling pollutants in the air.