Akademik Veri Yönetim Sistemi
Atatürk Üniversitesi Cerrahi Bilimler Dergisi, cilt.1, sa.3, ss.89-96, 2022 (Hakemli Dergi)
Objective: In this study, it was aimed to evaluate the correlation of malondialdehyde (MDA) levels in maternal blood, fetal
blood, and placental bed with fetomaternal Doppler values in preeclamptic pregnant women. Methods: The study was carried
out with a total of 74 cases, of whom 52 were healthy and 22 were pregnant with preeclampsia. Malondialdehyde levels were
measured in maternal blood, cord blood, and placenta tissues of the pregnant women. Doppler sonographic measurements were
carried out for the uterine and umbilical arteries. Doppler values and MDA levels of preeclamptic and healthy pregnant women
were compared. Results: Malondialdehyde levels in maternal blood and placental tissue in preeclamptic pregnant women were
significantly higher than healthy pregnant women (p<0.05). Although umbilical artery and umbilical vein MDA levels were
higher in the study group than in the control group, they were not statistically significant (p>0.05). Doppler sonographic indexes
in the umbilical and uterine arteries were significantly higher in the preeclamptic group than in the control group (p<0.05).
When all patients were evaluated, there was no significant correlation between maternal and placental malondialdehyde values
and umbilical and uterine artery Doppler values. Conclusion: Malondialdehyde levels and fetomaternal Doppler values in
blood and placental tissue were significantly higher in preeclamptic pregnant women compared to the control group. However,
no significant correlation was found between MDA levels and Doppler values.
Keywords: Oxidative stress, lipid peroxidation, malondialdehyde, Doppler sonography, placental insufficiency,
preeclampsia