Carbonic anhydrase inhibitory properties of phenolic sulfonamides derived from dopamine related compounds

GOCER H., AKINCIOGLU A., GÖKSU S., GÜLÇİN İ.

ARABIAN JOURNAL OF CHEMISTRY, cilt.10, sa.3, ss.398-402, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.arabjc.2014.08.005
  • Dergi Adı: ARABIAN JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.398-402
  • Anahtar Kelimeler: Phenolic sulfonamides, Carbonic anhydrase, Enzyme inhibition, Carbonic anhydrase, TROUT ONCORHYNCHUS-MYKISS, ERYTHROCYTES IN-VITRO, ENZYME-ACTIVITY, ISOZYMES I, ISOFORMS I, DERIVATIVES, PURIFICATION, ANTIOXIDANT, DANTROLENE, MELATONIN
  • Atatürk Üniversitesi Adresli: Evet

Özet

The effects of some phenolic sulfonamides were determined on the cytosolic carbonic anhydrase isoenzyme I and II (hCA I and II). Both isoenzymes were purified separately from human erythrocytes, using the Sepharose-4B-L-tyrosine-sulfanilamide affinity column chromatography method. In continuation of the study, we identified the inhibitory effects of phenolic sulfonamides 1-4 on the esterase activity of hCA I, and II. The inhibitory effects of phenolic sulfonamides 1-4 were tested on human carbonic anhydrase isoenzymes hCA I, and II. Among the compounds 14, compound 1 was concluded to show the best inhibitory effects. According to our data, IC50 values of compound 1 were found as 3.55 and 2.94 mu M for hCA I, and hCA II, respectively. On the other hand, K-i values of this compound were found as 0.827 and 0.745 mu M for both isoenzymes, respectively. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.