Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat

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Colluoglu C., Balci S., GÜNDOĞDU B., ÇOBAN T. A., Bulut S., SÜLEYMAN H.

BANGLADESH JOURNAL OF PHARMACOLOGY, cilt.17, sa.3, ss.72-78, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3329/bjp.v17i3.59418
  • Dergi Adı: BANGLADESH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.72-78
  • Atatürk Üniversitesi Adresli: Evet

Özet

This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examinations were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone attenuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage.