New PEPPSI-Pd-NHC complexes bearing 4-hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties

Behcet A., Taslimi P., GÖK Y., AKTAŞ A., TAŞKIN TOK T., GÜLÇİN İ.

ARCHIV DER PHARMAZIE, cilt.355, sa.12, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 355 Sayı: 12
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/ardp.202200276
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: alpha-glucosidase, enzyme inhibition, molecular docking, NHC complexes, PEPPSI, ALPHA-GLUCOSIDASE INHIBITORS, HETEROCYCLIC CARBENE COMPLEXES, CARBONIC-ANHYDRASE, CATALYTIC-ACTIVITY, CRYSTAL-STRUCTURE, ANTICANCER ACTIVITY, DERIVATIVES, POTENT, SALTS, IX
  • Atatürk Üniversitesi Adresli: Evet

Özet

Five 4-hydroxyphenylethyl substituted pyridine enhanced, precatalyst, preparation, stabilization, and initiation-Pd-N-heterocyclic carbene (PEPPSI-Pd-NHC) complexes are synthesized in a straightforward way. All PEPPSI-Pd-NHC complexes were prepared by mixing 4-hydroxyphenylethyl substituted NHC precursors, palladium chloride, potassium carbonate, and potassium bromide in pyridine. All complexes were screened for human carbonic anhydrase I (hCA I) and hCA II, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glucosidase (alpha-Glu) inhibitory activities. The ChE inhibitory activities of the new PEPPSI-Pd-NHC complexes bearing the 4-hydroxyphenylethyl group (12-e) against alpha-Glu, AChE, and BChE were determined by the Tao and Ellman methods. The results indicated that all the synthetic complexes exhibited potent inhibitory activities against all targets as compared to the standard inhibitors, revealed by IC50 values. The K-i values of the new PEPPSI-Pd-NHC complexes 1a-e for hCA I, hCA II, AChE, BChE, and alpha-Glu were obtained in the ranges of 18.98-32.65, 22.95-38.13, 3.67-11.65, 4.09-9.36, 186.92-287.45 mu M, respectively. Among the synthesized complexes, the most potent complexes were 1c toward hCA I and II with K-i values 18.98 and 22.95 mu M, and 1d toward AChE and BChE with K-i = 3.67 and 4.09 mu M, respectively.