Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

DEMİRYILMAZ İ., TURAN M. İ., KISAOĞLU A., GÜLABOĞLU M., Yılmaz İ., SÜLEYMAN H.

PHARMACOLOGICAL REPORTS, cilt.66, sa.4, ss.647-652, 2014 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.pharep.2014.02.015
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.647-652
  • Anahtar Kelimeler: Rat, Liver, Oxidant/antioxidant, Nimesulide, ISCHEMIA-REPERFUSION INJURY, LIPID-PEROXIDATION, OXIDATIVE STRESS, VITAMIN-C, ELECTROCHEMICAL DETECTION, FREE-RADICALS, DAMAGE, LIVER, ACID, CYCLOOXYGENASE-2
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced ischemia/reperfusion (I/R).