Akademik Veri Yönetim Sistemi
4th International Environmental Chemistry (EnviroChem) Congress, Antalya, Türkiye, 30 Ekim - 02 Kasım 2022
Moxifloxacin, one of the fluoroquinolones group, is a broad-spectrum antibiotic used in atypical pneumonia.1 Fluoroquinones have been shown to be effective against viruses, including SARS-CoV-2, in many in vitro experiments, and were among the antibiotics preferred in the treatment of Covid-19 in the pandemic.2 Carbon black (CB), a family of small particle size carbon pigments, is theoretically a potential candidate as a high-performance adsorbent because it has a large specific surface area3. CB can be added to the textile fabric surface as a coating or directly to the textile fabric4. The removal of Moxifloxacin from aqueous solutions by CB coated fabric were optimized by using central composite experimental design (CCD) involving response surface methodology (RSM) using with three significant independent factors including pH, ionic strength and antibiotic initial concentration. It is modeled as polynomial between the independent variable (absorption capacity) and the dependent variables mentioned above. The absorbed moxifloxacin was determined by HPLC method. The chromatographic separation was achieved on the reversed-phase Zorbax C18 column with the mobile phase consisting of phosphate buffer (25 mM, pH 2.5) and acetonitrile at 290 nm. The statistical significance of the quadratic regression equation demonstrated that the regression is statistically significant with P<0.01 obtained from the ANOVA for response surface quadratic model. In this case pH, ionic strength and antibiotic initial concentration are significant model terms and significantly affects the absorption capacity of Moxifloxacin. The best conditions, predicted by the model, for the removal of the Moxifloxacin (168.04 μg/cm2) is obtained at pH values of 9.06, ionic strength of 0.39 M and initial concentration of 4430 μg/L. In addition, Langmuir's classical isotherm model (at 0.39 M ionic strength and pH 9.06) was applied, and it was found to be in good agreement with the CCD model, with an estimated maximum absorption capacity of 161.3 μg/cm2.