Determination of Lidocaine HCl in commercially cream and injection forms by GC-FID method
Bioorganic and Medicinal Chemistry Reports, cilt.5, sa.1, ss.9-19, 2022 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 5 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.25135/bmcr.27.2204.2418
- Dergi Adı: Bioorganic and Medicinal Chemistry Reports
- Sayfa Sayıları: ss.9-19
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
In the present study, GC-FID method for the determination of lidocaine HCl in commercially creams and injection forms was developed and validated. The linearity of method was observed in the concentration range of 0.1-5.0 µg/mL. The accuracy (RE%) and precision (RSD%) values of the within-day and between-day of GC-FID method are less than 10.0% and 3.0%, respectively, and also limit of detection (LOD) and the limit of quantitation (LOQ) values were observed as 0.03 and 0.11 µg/mL, respectively. The analytical recovery value of lidocaine HCl was determined as 99.47% on average. As a result, it was concluded that the developed and validated GCFID method can be easily used in routine analyzes in quality control laboratories.