In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates

SENTURK M., TALAZ O., EKINCI D., CAVDAR H., KÜFREVİOĞLU Ö. İ.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.19, sa.13, ss.3661-3663, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 13
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.bmcl.2009.04.087
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3661-3663
  • Anahtar Kelimeler: Organic nitrates, Gulutathione reductase, Inhibition, Cancer, Antimalaria agent, TRYPANOTHIONE REDUCTASE, DISULFIDE-REDUCTASE, TRYPANOSOMA-CRUZI, ENZYME, SUBSTRATE, NITROGLYCERIN, PURIFICATION, EPOXIDES, BINDING, DRUGS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Glutathione reductase (GR), is responsible for the existence of GSH molecule, a crucial antioxidant against oxidative stress reagents. The antimalarial activities of some redox active compounds are attributed to their inhibition of antioxidant flavoenzyme glutathione reductase, and inhibitors are therefore expected to be useful for the treatment of malaria. Twelve organic nitrate derivatives were synthesized and treated with human erythrocyte GR. The molecules were identified as strong GR inhibitors and novel antimalaria candidates. (C) 2009 Elsevier Ltd. All rights reserved.