Akademik Veri Yönetim Sistemi
FORENSIC TOXICOLOGY, cilt.42, ss.125-141, 2024 (SCI-Expanded)
Purpose: There is very little information about the
toxicological and pathological effects of synthetic cannabinoids, which have
cannabis-like properties. This study was carried out to histopathologically,
hematologically, and biochemically determine the toxic effects of acute and
subacute exposure to a novel synthetic cannabinoid 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide
in internal organs of adult male rats.
Methods: The cannabinoid was injected
intraperitoneally at three doses (0.5, 1.0, and 2.0 mg/kg, body weight). The
cannabinoid was administered to acute groups for 2 days and to subacute groups
for 14 days. Observations were made for 14 days and various changes such as
mortality, injury, and illness were recorded daily. Hematological and biochemical
changes were evaluated and histopathological analyses in lung, liver, and
kidney tissues were also performed.
Results: No mortality was observed. It was
observed that there were fluctuations in hematological and serum biochemical parameters.
Among the oxidative
stress parameters, significant decreases in superoxide dismutase, catalase levels
and significant increases in lipid peroxidation levels were determined. Serious
pathological changes such as necrosis, vacuolation, congestion, and fibrosis
were observed in the organs in a dose-dependent and time-dependent manner. It
was also found that the synthetic cannabinoid triggered apoptosis in internal
organs. The results demonstrated that the most affected organ by the
cannabinoid was the kidney.
Conclusion: This study showed for the first time that
CUMYL-4CN-BINACA adversely affects healthy male rats. It can be estimated that
the abuse of the cannabinoid may harm human health in the same way.