Design and Optimization of a Novel Spectrophotometric Method using Response Surface Methodology for the Determination of Losartan Potassium in Pharmaceuticals

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DEMİRKAYA MİLOĞLU F., POLATDEMİR E., ŞENOL O., KADIOĞLU Y.

CURRENT PHARMACEUTICAL ANALYSIS, cilt.13, sa.6, ss.552-558, 2017 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 13 Sayı: 6
• Basım Tarihi: 2017
• Doi Numarası: 10.2174/1573412912666160922122340
• Dergi Adı: CURRENT PHARMACEUTICAL ANALYSIS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.552-558
• Anahtar Kelimeler: Response surface analysis, losartan potassium, pharmaceutical formulation, iodine, experimental design, spectroscopy, PERFORMANCE LIQUID-CHROMATOGRAPHY, DOSAGE FORMS, TABLETS, HYDROCHLOROTHIAZIDE, VALIDATION
• Atatürk Üniversitesi Adresli: Evet

Özet

Backround: A new spectrophotometric method based on the oxidation reaction between iodide and iodate in the presence of the carboxylic acid form of losartan potassium (LP) was developed for the estimation of LP in pharmaceutical products.