Design and Optimization of a Novel Spectrophotometric Method using Response Surface Methodology for the Determination of Losartan Potassium in Pharmaceuticals

DEMİRKAYA MİLOĞLU, Fatma; POLATDEMİR, Elmas; ŞENOL, Onur; KADIOĞLU, Yücel

doi:10.2174/1573412912666160922122340

Design and Optimization of a Novel Spectrophotometric Method using Response Surface Methodology for the Determination of Losartan Potassium in Pharmaceuticals

Atıf İçin Kopyala

DEMİRKAYA MİLOĞLU F., POLATDEMİR E., ŞENOL O., KADIOĞLU Y.

CURRENT PHARMACEUTICAL ANALYSIS, cilt.13, sa.6, ss.552-558, 2017 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 13 Sayı: 6
Basım Tarihi: 2017
Doi Numarası: 10.2174/1573412912666160922122340
Dergi Adı: CURRENT PHARMACEUTICAL ANALYSIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.552-558
Anahtar Kelimeler: Response surface analysis, losartan potassium, pharmaceutical formulation, iodine, experimental design, spectroscopy, PERFORMANCE LIQUID-CHROMATOGRAPHY, DOSAGE FORMS, TABLETS, HYDROCHLOROTHIAZIDE, VALIDATION
Atatürk Üniversitesi Adresli: Evet

Özet

Backround: A new spectrophotometric method based on the oxidation reaction between iodide and iodate in the presence of the carboxylic acid form of losartan potassium (LP) was developed for the estimation of LP in pharmaceutical products.