Importance of Serum Adropin Levels in Ischemic Stroke: A Prospective Clinical Study
EURASIAN JOURNAL OF EMERGENCY MEDICINE, sa.3, ss.190-195, 2023 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2023
- Doi Numarası: 10.4274/eajem.galenos.2023.03780
- Dergi Adı: EURASIAN JOURNAL OF EMERGENCY MEDICINE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.190-195
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
Aim: Stroke should be diagnosed quickly and accurately in emergency settings. This study investigated serum adropin levels as a novel biomarker in the diagnostic value of ischemic stroke.Materials and Methods: A prospective cross-sectional study was conducted in a tertiary university hospital. Serum adropin levels were measured at the time of the first arrival in ischemic stroke patients (n=46) and healthy control (n=45). In the ischemic stroke group, blood samples were retaken 72 h after arrival.Results: There was a significant difference between the ischemic stroke group and the control group regarding adropin values at arrival (2.67+0.63 vs. 2.34+0.69, respectively p=0.032). There was no significant difference between the other groups in terms of arrival values (p>0.05). Logistic regression analysis revealed a statistically significant difference between the ischemic stroke and control groups (odds ratio: 2.23; 95% confidence interval: 1.140-4.360, p=0.019). In the ischemic stroke group, the adropin level was statistically significantly decreased on the third day compared with the arrival (p=0.041). The adropin levels predicted ischemic stroke patients with 58.7% sensitivity and 59.4% specificity with the 2.49 ng/mL cut-off value (area under the cur ve=0.635).Conclusion: In this study, high serum adropin levels can be thought to be supportive in the diagnostic value of ischemic stroke.