4-Methylmorpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, andCoMFAstudy

Pesyan N. N., Rashidnejad H., Esmaeili M. A., Safari E., TUNÇ T., Alilou M., ...Daha Fazla

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, cilt.67, sa.9, ss.1679-1695, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 9
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/jccs.202000057
  • Dergi Adı: JOURNAL OF THE CHINESE CHEMICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, INSPEC
  • Sayfa Sayıları: ss.1679-1695
  • Atatürk Üniversitesi Adresli: Evet

Özet

The reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecularH-bonds. X-ray Crystallography, FT-IR, and(1)H and(13)C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.