The efficacy of spironolactone and surfactant treatment on HMGB1, CRP, IL-1 beta and TNF-alpha levels in acute lung injury

Naldan, Muhammet; Atalay, Conan; Coskun, Aysenur; Karaca, Muhammet; AYDIN, Yener; Dorman, Emrullah; Daloglu, Ferah; KÜRŞAD, Hüsnü; ARAZ, Ömer

doi:10.5606/tgkdc.dergisi.2015.10395

The efficacy of spironolactone and surfactant treatment on HMGB1, CRP, IL-1 beta and TNF-alpha levels in acute lung injury

Naldan M. E., Atalay C., Coskun A., Karaca M., AYDIN Y., Dorman E., ...Daha Fazla

TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, cilt.23, sa.3, ss.538-543, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23 Sayı: 3
Basım Tarihi: 2015
Doi Numarası: 10.5606/tgkdc.dergisi.2015.10395
Dergi Adı: TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.538-543
Atatürk Üniversitesi Adresli: Evet

Özet

Background: This study aims to compare high-mobility group box-1 (HMGB1), interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and C reactive protein (CRP) levels with spironolactone and surfactant treatment, investigate if spironolactone and surfactant treatment is effective, and evaluate the effect of this treatment on histopathologic changes in the lungs in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).