Magneto-liposomes: Stability of magnetic nanoparticles in suspension for drug delivery
Nanotechnology 2010: Advanced Materials, CNTs, Particles, Films and Composites - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, Anaheim, CA, Amerika Birleşik Devletleri, 21 - 24 Haziran 2010, cilt.1, ss.924-927, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Cilt numarası: 1
- Basıldığı Şehir: Anaheim, CA
- Basıldığı Ülke: Amerika Birleşik Devletleri
- Sayfa Sayıları: ss.924-927
- Anahtar Kelimeler: Drug loading, Liposome, Magneto-liposomes, SPIONs, Surface charge
- Atatürk Üniversitesi Adresli: Hayır
Özet
Superparamagnetic iron oxide nanoparticles (SPIONs) of diameter 30-50 nm have been synthesized and stabilized in suspension by one-pot fabrication of magneto-liposomes of diameter around 80nm. Magneto-liposomes have been prepared by mixing with optimum ratio of prefabricated SPIONs and multi lamellar vesicles (MLVs) under strong ultrasonic vibration. Magneto-liposome nanocomposites are stable in aqueous suspension at physiological pH (~7) for days. Surfaces of magneto-liposomes have been characterized by measuring zeta potential at physiological pH and Salmon sperm DNA binding/elution experiments. Stable magneto-liposome exhibited nearly neutral surfaces whereas bared SPIONs exhibited positive and MLVs exhibited negative surface charge at physiological pH (~7). SPIONs have been uniformly coated with liposomes evidenced from high binding and elution of Salmon sperm DNA unlike to bared SPIONs. Pro-drug (Mitomycin-C) entrapment into stable magneto-liposomes at physiological pH (~7) is under study and the results will be presented in the conference (NSTI2010).