The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats.

Şengül E., Gelen V., Gedikli S., Özkanlar S., Gür C., Çelebi F., ...Daha Fazla

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, cilt.92, ss.303-307, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.biopha.2017.05.047
  • Dergi Adı: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.303-307
  • Anahtar Kelimeler: Quercetin, Cyclophosphamide, Lung-toxicity, Rat, Mast cell, INDUCED PULMONARY INJURY, OXIDATIVE STRESS, IN-VITRO, ANTIOXIDANT, MICE, MODULATION, CYSTITIS, EXTRACT, DISEASE, CELLS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Cyclophosphamide (CYP) is an anticancer agent widely used in chemotherapy. It has been suggested that CYP causes toxicity in many organs, including the lungs and testes. Many studies have indicated that some antioxidants have possible protective effects against CYP's side effects. This study aimed to investigate the protective effect of quercetin (QUE) on CYP-induced lung toxicity in rats using histologic and biochemical methods.