The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats.

Şengül, Emin; Gelen, Volkan; Gedikli, Semin; Özkanlar, Seçkin; Gür, Cihan; Çelebi, Fikret; Çınar, Dursunali

doi:10.1016/j.biopha.2017.05.047

The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats.

Şengül E., Gelen V., Gedikli S., Özkanlar S., Gür C., Çelebi F., ...More

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol.92, pp.303-307, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 92
Publication Date: 2017
Doi Number: 10.1016/j.biopha.2017.05.047
Journal Name: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.303-307
Keywords: Quercetin, Cyclophosphamide, Lung-toxicity, Rat, Mast cell
Ataturk University Affiliated: Yes

Abstract

Cyclophosphamide (CYP) is an anticancer agent widely used in chemotherapy. It has been suggested that CYP causes toxicity in many organs, including the lungs and testes. Many studies have indicated that some antioxidants have possible protective effects against CYP's side effects. This study aimed to investigate the protective effect of quercetin (QUE) on CYP-induced lung toxicity in rats using histologic and biochemical methods.