The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats.

Şengül, Emin; Gelen, Volkan; Gedikli, Semin; Özkanlar, Seçkin; Gür, Cihan; Çelebi, Fikret; Çınar, Dursunali

doi:10.1016/j.biopha.2017.05.047

The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats.

Atıf İçin Kopyala

Şengül E., Gelen V., Gedikli S., Özkanlar S., Gür C., Çelebi F., ...Daha Fazla

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, cilt.92, ss.303-307, 2017 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 92
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.biopha.2017.05.047
Dergi Adı: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.303-307
Anahtar Kelimeler: Quercetin, Cyclophosphamide, Lung-toxicity, Rat, Mast cell
Atatürk Üniversitesi Adresli: Evet

Özet

Cyclophosphamide (CYP) is an anticancer agent widely used in chemotherapy. It has been suggested that CYP causes toxicity in many organs, including the lungs and testes. Many studies have indicated that some antioxidants have possible protective effects against CYP's side effects. This study aimed to investigate the protective effect of quercetin (QUE) on CYP-induced lung toxicity in rats using histologic and biochemical methods.