Recent Advances in Nickel Catalysts for Sonogashira Coupling
ChemistryOpen, vol.15, no.5, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 15 Issue: 5
- Publication Date: 2026
- Doi Number: 10.1002/open.70217
- Journal Name: ChemistryOpen
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, EMBASE, MEDLINE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Keywords: aryl halides, coupling reaction, nickel catalyst, sonogashira reaction, terminal alkynes
- Ataturk University Affiliated: Yes
Abstract
The Sonogashira coupling, catalyzed by transition metals, has become a valuable method for forming carbon-carbon bonds. While palladium-copper was originally recognized as the most effective catalyst for this transformation, recent advances have highlighted the growing prominence of nickel-catalyzed Sonogashira reactions. Nickel has gained considerable interest due to its lower cost and more environmentally friendly profile compared to palladium. This review focuses on recent progress in nickel-catalyzed Sonogashira coupling, surveying studies published between 2021 and 2025.