Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives

Ozkan H., Gultekin D., SEZEN S., Ozgeris B., GÜLLÜCE M., Tumer F.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.31, sa.12, ss.1252-1257, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 12
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/0748233713491810
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1252-1257
  • Anahtar Kelimeler: Mutagenicity, Ames, Salmonella, E. coli WP2, synthetic pyridine compounds, EASTERN ANATOLIA REGION, GENOTOXICITY, BIOACTIVITY, VULGARE, EXTRACT, ASSAY, ACID, UREA
  • Atatürk Üniversitesi Adresli: Evet

Özet

Nowadays, there are increasing numbers of studies about synthetic chemicals according to the supply demands of bioactive chemicals. The current study aims to investigate genotoxic potential of bioactive synthetic pyridine compounds, phenyl-3-pyridinylmethanone (1), p-tolyl-3-pyridinylmethanone (2), and 4-methoxyphenyl-3-pyridinylmethanone (3), using Ames/Salmonella and Escherichia coli WP2 bacterial reversion mutagenicity test systems. The mutant bacterial tester strains sodium azide-sensitive Salmonella typhimurium TA1535, 9-aminoacridine-sensitive S. typhimurium TA1537, and N-methyl-N-nitro-N-nitrosoguanidine-sensitive E. coli WP2uvrA were used to detect the mutagenic potential of the test compounds. The results indicated that none of the test substances showed significant mutagenic activity on S. typhimurium TA1535, TA1537, and E. coli WP2uvrA bacterial strains up to 1 mu g/plate concentrations.