A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

Akdemir F. N. E., GÜLÇİN İ., Karagoz B., Soslu R., ALWASEL S. H.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.31, ss.114-118, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1080/14756366.2016.1220378
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.114-118
  • Anahtar Kelimeler: Antioxidant activity, ellagic acid, hesperidin, ischemia/reperfusion injury, skeletal muscle, ISCHEMIA-REPERFUSION INJURY, INDUCED OXIDATIVE STRESS, IN-VITRO ANTIOXIDANT, RADICAL SCAVENGING ACTIVITIES, LYOPHILIZED AQUEOUS EXTRACT, POLYPHENOL CONTENTS, PHENOLIC-COMPOUNDS, CAFFEIC ACID, ANTIRADICAL ACTIVITIES, LUNG CARCINOGENESIS
  • Atatürk Üniversitesi Adresli: Evet

Özet

The antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2 h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2 h. EA (100 mg/kg) has been applied orally before ischemia/reperfusion in the EA+I/R group. HES (100 mg/kg) has been given orally in the HES+1/R group. The left gastrocnemius muscle has been harvested and stored immediately at -80 degrees C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p<0.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p<0.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA+I/R and HES+I/R groups.