In vitro inhibition of alpha-carbonic anhydrase isozymes by some phenolic compounds

Sarikaya S. B. O., TOPAL F., Senturk M., GÜLÇİN İ., SUPURAN C. T.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.21, sa.14, ss.4259-4262, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 14
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.bmcl.2011.05.071
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4259-4262
  • Anahtar Kelimeler: Tannic acid, Pyrogallol, Carbonic anhydrase, Inhibition, hCA-I, hCA-II, hCA VI, dCA, Antiglaucoma, ERYTHROCYTE GLUTATHIONE-REDUCTASE, THERAPEUTIC APPLICATIONS, ESTERASE-ACTIVITIES, METAL-COMPLEXES, SULFONAMIDES, DRUGS, THIOXOLONE, ACTIVATORS, BINDING, VI
  • Atatürk Üniversitesi Adresli: Evet

Özet

Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or osteoporosis. We report here the inhibitory capacities of some phenolic compounds against three human CA isozymes (hCA I, hCA II, and hCA VI) and the gill carbonic anhydrase of the teleost fish Dicentrarchus labrax (European seabass) (dCA). The isozymes showed quite diverse inhibition profiles with these compounds. These data may lead to design novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.